Study prescription and over-the-counter medication - how they work, doable unwanted effects, and extra. This drugs must be began concurrently therapy with a luteinizing hormone-releasing hormone (LHRH) analog (eg, goserelin, leuprolide, Lupron®, or Zoladex®). Add-back therapy can help scale back the bone loss that occurs with the usage of LUPRON DEPOT alone.
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In contrast, bicalutamide has no effect or has a weak and transient inhibitory effect on the vast majority of tumors that recur after androgen deprivation by castration or luteinizing hormone-releasing hormone agonist therapy. Bic at dose ≥30 μM dose-dependently downregulated the nuclear AR (p < zero.05) (Fig.
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